As if a fixture between England’s two most successful clubs needed additional incentives, the victors will either remain top in the case of United or return to the summit of the table in the case of the Reds.
The German has seen his squad decimated at times by injury and will be hoping for a change in fortunes as the second half of the campaign comes around.
The build-up to this clash has perhaps been heightened more than most of late, as the club from down the East Lancashire road head to Merseyside in a far better place than in recent years.
With Joel Matip facing a race against time to make the kick-off and Klopp’s selection hampered by continued injury absentees, we’ve predicted the lineup we think the Reds manager will select, with six changes from the side which began the recent FA Cup win at Aston Villa.
GK - Alisson Becker
More important than ever as Liverpool look to fight for top honours without their recognised centre-backs. He comes back in for Caoimhin Kelleher.
RB - Trent Alexander-Arnold
Hasn’t featured since coming in for criticism after the Southampton match.
Rest may have been just the tonic as he has looked desperately short of form
CB - Nat Phillips
Hugely dependant on how Matip pulled up. Phillips has proven to be solid in his fleeting appearances.
His aerial strength could be important should Edinson Cavani feature and he may come in for Rhys Williams.
CB - Fabinho
Sternest test to date coming up but he has the capabilities to cope
LB - Andy Robertson
Arguably the Reds’ best player this season and he will come back in to replace James Milner.
His influence going forward and pushing United back will be imperative
CM - Jordan Henderson
Having covered at centre-back recently, his absence from the midfield was all too apparent.
Needs to lead the side from the engine room today
CM - Thiago
Having a growing influence as he continues to settle into life with Liverpool.
No better match to announce himself fully
CM - Gini Wijnaldum
His industry and clever positioning will be crucial to keep the United midfielders occupied defensively.
RW - Mohamed Salah
Big game player who will be desperate to send a message to his doubters
RW - Sadio Mane
Two goals against a young Aston Villa side in the FA Cup may have come at a good time.
Needs to click back into gear.
CF - Roberto Firmino
His form can be the difference-maker between good and bad Liverpool performances.
If he plays well, the wingers in particular seem to follow suit