The 29-year-old was replaced before the half-hour mark as the Lions drew 1-1 in a World Cup qualifier.
Mane appeared to be distraught with the situation, causing Kopites to panic having already lost a host of key players in recent weeks.
However, Senegal manager Aliou Cisse acted to cool fears in his post-match interview.
Reds’ boss has already had to cope without Harvey Elliott, Thiago, Fabinho and Naby Keita as well as facing a prolonged spell without Roberto Firmino.
So far this season Mane has looked back to his brilliant best, scoring eight times in 15 appearances.
Meanwhile, Takumi Minamino assisted the only goal of the game as Japan overcame Vietnam whilst Kostas Tsimikas played 90 minutes for Greece.
Alisson kept a clean sheet overnight for Brazil as Fabinho came on for the final five minutes.
READ LIVERPOOL VERDICT
This was very nearly all Kopites’ nightmares coming at once.
Already down to the bare bones somewhat in terms of attacking and midfield options, Liverpool need a clean bill of health across this break in order to come back firing on all cylinders.
Today (Friday 12 November), Mohamed Salah’s Egypt take on Angola and Scotland captain Andy Robertson is almost certain to feature prominently against Moldova.